The role of innate immune system mediators in the development of retinal neurodegeneration in type 2 diabetes mellitus

Purpose. To detect the levels of transform growth factors- β (TGF- β1 , TGF- β2 β3) interferon- ʏ (INF- ), matrix metalloproteinase-9 (MMP-9) and S100B protein in blood serum patients with type 2 diabetes mellitus (DM) to reveal connection these factors neurodegenerative changes retina. Material methods. 30 patients, averagely aged 60.3, DM no signs diabetic retinopathy (DR) (the main group) healthy individuals (control were examined using microperimetry optical coherence tomography. A sandwich variance estimator solid phase enzyme-linked immunosorbent assay was used determine 1 β3, INF- ʏ, ММР -9 subjects examined. Results. The found experience an increased level focal loss retinal ganglion cells a drop average photosensitivity group also showed reliable increase MMP-9 against control, but significant difference between groups TIMP-1. significantly higher group, which deficiency β3. No two or . In contrast, positive correlation revealed S100B, volume cells. Conclusion. Patients neurodegeneration retina activity some cytokines MMP-9. This may indicate important role neuroinflammation dysfunction immune system process patients. Further research other cytokins is required early more sensitive markers neurodegeneration.